Advanced Veterinary Oncology: A Leap Forward in Pet Cancer Care





The UC Davis School of Veterinary Medicine's Comparative Cancer Center is transforming the landscape of pet cancer treatment through its innovative diagnostic capabilities and advanced therapeutic approaches. A notable success story is that of Klydee, an 11-year-old female terrier mix from Honolulu. Diagnosed with a severe eye tumor that led to blindness and later a brain tumor, Klydee received life-saving neurosurgery and radiation therapy at UC Davis, a testament to the center's specialized care not available in her home state. This complex procedure, performed by neurosurgeons Dr. Ji-Hey Lim, Dr. Adrien Dupanloup, and Dr. Vishal Murthy, utilized a cutting-edge surgical microscope, a gift from the Meadowview Foundation, which provided unprecedented magnification and precision, enabling less invasive tumor removal and improved surgical margins. Dr. Dupanloup emphasized the microscope's critical role in both clinical treatment and ongoing research to optimize tumor removal.
Annually, nearly 3,000 animals benefit from the center's expertise, which has seen substantial growth since its inception in 2007. Initially evolving from the Cancer Biology in Animals program, it integrated the School of Veterinary Medicine with the UC Davis NCI Designated Comprehensive Cancer Center, establishing the first cross-species cancer research program in the U.S. The center's physical footprint is projected to double to 36,000 square feet by the end of the decade, facilitating expanded clinical services. This expansion also includes the state-of-the-art All Species Imaging Center, launched in September 2025, which features advanced diagnostic tools like small animal CT, high-field MRI, and PET/CT scanners capable of imaging diverse species from horses to llamas. Dr. Mathieu Spriet, Director of Imaging Services, highlights these advancements for enabling previously impossible imaging and improving patient care. Dr. Jessica Lawrence, Professor of Radiation Oncology, underscores the importance of this sophisticated equipment combined with a dedicated staff, as it attracts top talent and fosters an environment of continuous improvement in patient care.
Beyond clinical care, research is a cornerstone of the Comparative Cancer Center's mission, with a strong emphasis on translational studies that benefit both animal and human health. The center actively fosters future oncology researchers through programs like the DVM Ph.D. program, which offers NIH support for those pursuing careers in comparative oncology. Recent research endeavors include exploring alternative gemcitabine administration methods in dogs, investigating canine immune systems against metastatic cancer, and identifying genetic variants linked to increased lifespan in Golden Retrievers. Dr. Michael Kent, Director of the Center for Companion Animal Health and Co-Program Leader of the Comparative Oncology Program, envisions continued growth in training, clinical trials, and foundational science, striving to establish the most comprehensive cancer program globally. This dedication ensures that advancements in veterinary oncology not only save animal lives but also contribute invaluable knowledge to the broader fight against cancer, embodying a holistic approach to health and scientific discovery.